plasma protein binding pyew citer..

assalamualaikum..

seperti biasa, kalo nk exam, smakin byk lha bnda yg aq xfaham.. padahal, aq da study psal tu koet.. but, isokey.. just relax and study..

esok, aku ade exam utk paper farmaco.. ni exam final sem okay.. bkn exam cincai n biasa2 jerk.. 40% mark  is waiting.. huhuuuu..

and skrg ni, aq ade problem utk faham psal plasma protein binding.. bnda ni simple jerk sbnarnye.. tp ntah lha knape.. maybe sbb aq ngntuk kot skrg..sbb tu ssh ckit nk fham.. smua laman aq bkk.. youtube, google, medical book online, and bla3 (selain slide yg Dr Reezal bg)..

and ni ape yg aq faham.. and insyaAllah lekat kat otak ni sbagaimana drug bind kt reseptor.. and harap aq akn igt smpai bila2.. insyaAllah.. amin..

BINDING OF DRUG TO PLASMA MEMBRANE


Plasma Protein Binding 
 Almost all drugs are reversibly bound to plasma proteins,
primarily albumin , but also lipoproteins, glycoproteins, and
β globulins. The extent of binding depends on the affinity of
a particular drug for protein-binding sites and ranges from
less than 10% to as high as 99% of the plasma concentration.
As the free (unbound) drug diffuses into interstitial fluid
and cells, drug molecules dissociate from plasma proteins
to maintain the equilibrium between free drug and bound
drug. In general, acid drugs bind to albumin and basic drugs
to glycoproteins and β globulins.
 Plasma protein binding is saturable , and a drug can be
displaced from binding sites by other drugs that have a high
affinity for such sites. However, most drugs are not used at
high enough plasma concentrations to occupy the vast number of plasma protein binding sites. There are a few agents
that may cause drug interactions by competing for plasma
protein binding sites, as highlighted in Chapter 4.

ni text yg tlg aq faham psal binding ni... http://www.us.elsevierhealth.com/media/us/samplechapters/9781416066279/Chapter%2002.pdf..

and sebagai ksimpulannya..

• proses ni blaku dlm fasa distribution (drug molecul will absorb from plasma protein to interstitial fluid)
• drug molecul will be bind to plasma membrane
• molekul dadah akn trapped dan xactive. so, hya molekul yg still free time tu yg dapat btindak balas or bg response
• ciri2 binding : reversible (mampu diterbalikkan), non specific (xspesifik), n non selective (xpilih)
  
  *amboi.. siap translate lg.. huhu~~

tu jerk kot yg aq faham.. k lha.. bcoz of aq sgt3 ngntuk skrg ni, aq kna tdo lu.. so, chow.. bubye..